EC 220.127.116.11 - Phenylalanine aminomutase (D-β-phenylalanine forming)
IntEnz Enzyme Nomenclature
L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate]
- L-phenylalanine = D-beta-phenylalanine
The enzyme from the bacterium Pantoea agglomerans produces D-β-phenylalanine, an intermediate in the biosynthesis of the polyketide non-ribosomal antibiotic andrimid. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 18.104.22.168, phenylalanine aminomutase (L-β-phenylalanine forming).
Links to other databases
Stereochemistry and mechanism of a microbial phenylalanine aminomutase.J. Am. Chem. Soc. 133 : 8531-8533 (2011). [PMID: 21561099]
[EC 22.214.171.124 created 2013]