EC 5.4.3.10 - Phenylalanine aminomutase (L-β-phenylalanine forming)

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IntEnz Enzyme Nomenclature
EC 5.4.3.10

Names

Accepted name:
phenylalanine aminomutase (L-β-phenylalanine forming)
Systematic name:
L-phenylalanine 2,3-aminomutase [(R)-3-amino-3-phenylpropanoate forming]

Reaction

Cofactor

Comments:

The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO). This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.11, phenylalanine aminomutase (D-β-phenylalanine forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Feng, L., Wanninayake, U., Strom, S., Geiger, J., Walker, K. D.
    Mechanistic, mutational, and structural evaluation of a Taxus phenylalanine aminomutase.
    Biochemistry 50 : 2919-2930 (2011). [PMID: 21361343]

[EC 5.4.3.10 created 2013]