EC 5.4.1.3 - 2-methylfumaryl-CoA isomerase

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IntEnz Enzyme Nomenclature
EC 5.4.1.3

Names

Accepted name:
2-methylfumaryl-CoA isomerase
Other names:
mesaconyl-CoA C1-C4 CoA transferase
Mct
Systematic name:
2-methylfumaryl-CoA 1,4-CoA-mutase

Reaction

Comments:

The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Zarzycki, J., Brecht, V., Muller, M., Fuchs, G.
    Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
    Proc. Natl. Acad. Sci. U.S.A. 106 : 21317-21322 (2009). [PMID: 19955419]

[EC 5.4.1.3 created 2014]