EC - Prostaglandin-E synthase

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IntEnz Enzyme Nomenclature


Accepted name:
prostaglandin-E synthase
Other names:
PGE isomerase
PGE2 isomerase
PGH-PGE isomerase
endoperoxide isomerase
prostaglandin H-E isomerase
prostaglandin R-prostaglandin E isomerase
prostaglandin endoperoxide E isomerase
prostaglandin endoperoxide E2 isomerase
prostaglandin-H2 E-isomerase
Systematic name:
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase




Brings about the opening of the epidioxy bridge. Requires glutathione.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050220
CAS Registry Number: 52227-79-9
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Ogino, N., Miyamoto, T., Yamamoto, S. and Hayaishi, O.
    Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme.
    J. Biol. Chem. 252: 890-895 (1977). [PMID: 838703]
  2. Tanaka, Y., Ward, S.L. and Smith, W.L.
    Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes.
    J. Biol. Chem. 262: 1374-1381 (1987). [PMID: 3100531]

[EC created 1976, modified 1990]