EC 5.3.99.2 - Prostaglandin-D synthase

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IntEnz Enzyme Nomenclature
EC 5.3.99.2

Names

Accepted name:
prostaglandin-D synthase
Other names:
PGH-PGD isomerase
prostaglandin-H2 Δ-isomerase
prostaglandin-R-prostaglandin D isomerase
prostaglandin D2 synthase
PGD2 synthase
(5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate Δ-isomerase [incorrect]
(5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
prostaglandin endoperoxide Δ-isomerase
prostaglandin D synthetase
Systematic name:
(5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase

Reaction

Cofactor

Comments:

Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00187
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004667
CAS Registry Number: 65802-85-9
UniProtKB/Swiss-Prot: (17) [show] [UniProt]

References

  1. Christ-Hazelhof, E. and Nugteren, D.H.
    Purification and characterisation of prostaglandin endoperoxide Δ-isomerase, a cytoplasmic, glutathione-requiring enzyme.
    Biochim. Biophys. Acta 572: 43-51 (1979). [PMID: 32914]
  2. Shimizu, T., Yamamoto, S. and Hayaishi, O.
    Purification and properties of prostaglandin D synthetase from rat brain.
    J. Biol. Chem. 254: 5222-5228 (1979). [PMID: 109431]

[EC 5.3.99.2 created 1976, modified 1990]