EC 5.3.99.11 - 2-keto-myo-inositol isomerase

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IntEnz Enzyme Nomenclature
EC 5.3.99.11

Names

Accepted name:
2-keto-myo-inositol isomerase
Other names:
inosose isomerase
2KMI isomerase
IolI
Systematic name:
2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase

Reaction

Cofactor

Comments:

Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Zhang, R. G., Dementieva, I., Duke, N., Collart, F., Quaite-Randall, E., Alkire, R., Dieckman, L., Maltsev, N., Korolev, O., Joachimiak, A.
    Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding.
    Proteins 48 : 423-426 (2002). [PMID: 12112707]
  2. Yoshida, K., Yamaguchi, M., Morinaga, T., Ikeuchi, M., Kinehara, M., Ashida, H.
    Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
    Appl. Environ. Microbiol. 72 : 1310-1315 (2006). [PMID: 16461681]

[EC 5.3.99.11 created 2014]