EC - Protein disulfide-isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
protein disulfide-isomerase
Other name:
S-S rearrangase
Systematic name:
protein disulfide-isomerase



Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00172
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003756
CAS Registry Number: 37318-49-3
UniProtKB/Swiss-Prot: (90) [show] [UniProt]


  1. De Lorenzo, F., Goldberger, R.F., Steers, E., Givol, D. and Anfinsen, C.B.
    Purification and properties of an enzyme from beef liver which catalyzes sulfhydryl-disulfide interchange in proteins.
    J. Biol. Chem. 241: 1562-1567 (1966). [PMID: 5946614]
  2. Fuchs, S., De Lorenzo, F. and Anfinsen, C.B.
    Studies on the mechanism of the enzymic catalysis of disulfide interchange in proteins.
    J. Biol. Chem. 242: 398-402 (1967). [PMID: 6022836]

[EC created 1972]