EC - Lutein isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
lutein isomerase
Other names:
RPE65 (gene name)
meso-zeaxanthin isomerase
Systematic name:
lutein Δ45-isomerase



The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC, retinoid isomerohydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M. P., Bernstein, P. S.
    RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye.
    Proc. Natl. Acad. Sci. U.S.A. 114: 10882-10887 (2017). [PMID: 28874556]

[EC created 2018]