EC - Δ3,52,4-dienoyl-CoA isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
Δ3,52,4-dienoyl-CoA isomerase
Other names:
3,5-tetradecadienoyl-CoA isomerase
DCI1 (gene name)
Systematic name:
(3E,5Z)-alka-3,5-dienoyl-CoA Δ3,52,4 isomerase



The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Filppula, S. A., Yagi, A. I., Kilpelainen, S. H., Novikov, D., FitzPatrick, D. R., Vihinen, M., Valle, D., Hiltunen, J. K.
    Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization.
    J. Biol. Chem. 273 : 349-355 (1998). [PMID: 9417087]
  2. Modis, Y., Filppula, S. A., Novikov, D. K., Norledge, B., Hiltunen, J. K., Wierenga, R. K.
    The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
    Structure 6 : 957-970 (1998). [PMID: 9739087]
  3. Geisbrecht, B. V., Schulz, K., Nau, K., Geraghty, M. T., Schulz, H., Erdmann, R., Gould, S. J.
    Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
    Biochem. Biophys. Res. Commun. 260 : 28-34 (1999). [PMID: 10381339]
  4. Gurvitz, A., Mursula, A. M., Yagi, A. I., Hartig, A., Ruis, H., Rottensteiner, H., Hiltunen, J. K.
    Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase.
    J. Biol. Chem. 274 : 24514-24521 (1999). [PMID: 10455114]
  5. Zhang, D., Liang, X., He, X. Y., Alipui, O. D., Yang, S. Y., Schulz, H.
    Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study.
    J. Biol. Chem. 276 : 13622-13627 (2001). [PMID: 11278886]
  6. Goepfert, S., Vidoudez, C., Rezzonico, E., Hiltunen, J. K., Poirier, Y.
    Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids.
    Plant Physiol. 138 : 1947-1956 (2005). [PMID: 16040662]

[EC created 2018]