EC - Isopentenyl-diphosphate Δ-isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
isopentenyl-diphosphate Δ-isomerase
Other names:
isopentenylpyrophosphate Δ-isomerase
isopentenylpyrophosphate isomerase
methylbutenylpyrophosphate isomerase
IPP isomerase
Systematic name:
isopentenyl-diphosphate Δ32-isomerase




The enzyme from Streptomyces sp. strain CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004452
CAS Registry Number: 9033-27-6
UniProtKB/Swiss-Prot: (276) [show] [UniProt]


  1. Kaneda, K., Kuzuyama, T., Takagi, M., Hayakawa, Y. and Seto, H.
    An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
    Proc. Natl. Acad. Sci. USA 98: 932-937 (2001). [PMID: 11158573]
  2. Bishop, J.M.
    Cellular oncogenes and retroviruses.
    Annu. Rev. Biochem. 52: 301-354 (1983). [PMID: 6351725]
  3. Agranoff, B.W., Eggerer, H., Henning, U. and Lynen, F.
    Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase.
    J. Biol. Chem. 235: 326-332 (1960).

[EC created 1961, modified 2002]