EC 5.3.3.18 - 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 5.3.3.18

Names

Accepted name:
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
Other names:
paaG (gene name)
1,2-epoxyphenylacetyl-CoA isomerase [misleading]
Systematic name:
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

Reaction

Comments:

The enzyme catalyses the reversible isomerization of 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen-containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)-ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Ismail, W., El-Said Mohamed, M., Wanner, B. L., Datsenko, K. A., Eisenreich, W., Rohdich, F., Bacher, A., Fuchs, G.
    Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli.
    Eur. J. Biochem. 270 : 3047-3054 (2003). [PMID: 12846838]
  2. Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W., Fuchs, G.
    Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
    Proc. Natl. Acad. Sci. U.S.A. 107 : 14390-14395 (2010). [PMID: 20660314]

[EC 5.3.3.18 created 2011]