EC - 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
Other names:
paaG (gene name)
1,2-epoxyphenylacetyl-CoA isomerase [misleading]
Systematic name:
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase



The enzyme catalyses the reversible isomerization of 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen-containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)-ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Ismail, W., El-Said Mohamed, M., Wanner, B. L., Datsenko, K. A., Eisenreich, W., Rohdich, F., Bacher, A., Fuchs, G.
    Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli.
    Eur. J. Biochem. 270 : 3047-3054 (2003). [PMID: 12846838]
  2. Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W., Fuchs, G.
    Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
    Proc. Natl. Acad. Sci. U.S.A. 107 : 14390-14395 (2010). [PMID: 20660314]

[EC created 2011]