EC - Polyenoic fatty acid isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
polyenoic fatty acid isomerase
Other names:
eicosapentaenoate cis5,8,11,14,17-eicosapentaenoate cis5-trans7,9-cis14,17 isomerase
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,117,8-isomerase [incorrect]
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,117,9-isomerase (trans-double-bond-forming)
Systematic name:
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Δ8,117,9-isomerase (trans-double-bond-forming)



The enzyme from the red alga Ptilota filicina catalyses the isomerization of skip dienes (methylene-interrupted double bonds) in a broad range of fatty acids and fatty-acid analogues, such as arachidonate and γ-linolenate, to yield a conjugated triene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034016


  1. Wise, M.L., Hamberg, M. and Gerwick, W.H.
    Biosynthesis of conjugated fatty acids by a novel isomerase from the red marine alga Ptilota filicina.
    Biochemistry 33: 15223-15232 (1994). [PMID: 7803384]
  2. Wise, M.L., Soderstrom, K., Murray, T.F. and Gerwick, W.H.
    Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid.
    Experientia 52: 88-92 (1996). [PMID: 8575565]
  3. Wise, M.L., Rossi, J. and Gerwick, W.H.
    Binding site characterization of polyenoic fatty-acid isomerase from the marine alga Ptilota filicina.
    Biochemistry 36: 2985-2992 (1997). [PMID: 9062129]
  4. Zheng, W., Wise, M.L., Wyrick, A., Metz, J.G., Yuan, L. and Gerwick, W.H.
    Polyenoic fatty-acid isomerase from the marine red alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA.
    Arch. Biochem. Biophys. 401: 11-20 (2002). [PMID: 12054482]

[EC created 2004]