EC 5.3.3.12 - L-dopachrome isomerase

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IntEnz Enzyme Nomenclature
EC 5.3.3.12

Names

Accepted name:
L-dopachrome isomerase
Other names:
DCF
DCT
dopachrome Δ-isomerase
dopachrome Δ72-isomerase
dopachrome conversion factor
dopachrome oxidoreductase
dopachrome tautomerase
dopachrome-rearranging enzyme
tyrosinase-related protein 2
TRP-1
TRP2
TRP-2
tryosinase-related protein-2
dopachrome isomerase
dopachrome keto-enol isomerase
L-dopachrome-methyl ester tautomerase
Systematic name:
L-dopachrome keto-enol isomerase

Reaction

Cofactor

Comments:

A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00398
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004167
CAS Registry Number: 130122-81-5
UniProtKB/Swiss-Prot: (24) [show] [UniProt]

References

  1. Solano, F., Jiménez-Cervantes, C., Martínez-Liarte, J.H., García-Borrón, J.C. and Lozano, J.A.
    Molecular mechanism for catalysis by a new zinc enzyme, dopachrome tautomerase.
    Biochem. J. 313: 447-453 (1996). [PMID: 8573077]
  2. Pawelek, J.M.
    Dopachrome conversion factor functions as an isomerase.
    Biochem. Biophys. Res. Commun. 166: 1328-1333 (1990). [PMID: 2106316]
  3. Pennock, J.L., Behnke, J.M., Bickle, Q.D., Devaney, E., Grencis, R.K., Isaac, R.E., Joshua, G.W.P., Selkirk, M.E., Zhang, Y. and Meyer, D.J.
    Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
    Biochem. J. 335: 495-498 (1998). [PMID: 9794786]

[EC 5.3.3.12 created 1992, modified 1999, modified 2005]