EC - 5-carboxymethyl-2-hydroxymuconate Δ-isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
5-carboxymethyl-2-hydroxymuconate Δ-isomerase
Other names:
CHM isomerase
5-carboxymethyl-2-hydroxymuconic acid isomerase
Systematic name:
5-carboxymethyl-2-hydroxymuconate Δ24-2-oxo,Δ3-isomerase



Part of the homoprotocatechuate degradation pathway in Escherichia coli C.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008704


  1. Garrido-Pertierra, A. and Cooper, R.A.
    Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
    Eur. J. Biochem. 117 : 581-584 (1981). [PMID: 7026235]
  2. Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P.
    Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications.
    J. Am. Chem. Soc. 117 : 8719-8726 (1995).

[EC created 1984]