EC 5.3.2.3 - TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-galactopyranose-forming)

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IntEnz Enzyme Nomenclature
EC 5.3.2.3

Names

Accepted name:
TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-galactopyranose-forming)
Other names:
dTDP-6-deoxy-hex-4-ulose isomerase
TDP-6-deoxy-hex-4-ulose isomerase
FdtA
Systematic name:
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose:dTDP-3-dehydro-6-deoxy-α-D-galactopyranose isomerase

Reaction

Comments:

The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-D-galactose. Four moieties of α-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-α-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Pfoestl, A., Hofinger, A., Kosma, P., Messner, P.
    Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
    J. Biol. Chem. 278 : 26410-26417 (2003). [PMID: 12740380]
  2. Davis, M. L., Thoden, J. B., Holden, H. M.
    The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
    J. Biol. Chem. 282 : 19227-19236 (2007). [PMID: 17459872]

[EC 5.3.2.3 created 2011]