EC - (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase
Other names:
lsrG (gene name)
phospho-AI-2 isomerase
Systematic name:
(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase



The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (26) [show] [UniProt]


  1. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J., Pelczer, I., Semmelhack, M. F., Bassler, B. L.
    Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
    ACS Chem. Biol. 2 : 128-136 (2007). [PMID: 17274596]
  2. Marques, J. C., Lamosa, P., Russell, C., Ventura, R., Maycock, C., Semmelhack, M. F., Miller, S. T., Xavier, K. B.
    Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.
    J. Biol. Chem. 286 : 18331-18343 (2011). [PMID: 21454635]

[EC created 2015]