EC - D-sedoheptulose-7-phosphate isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
D-sedoheptulose-7-phosphate isomerase
Other names:
sedoheptulose-7-phosphate isomerase
phosphoheptose isomerase
Systematic name:
D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase



In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (208) [show] [UniProt]


  1. Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M. A., Messner, P.
    Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli.
    J. Bacteriol. 184 : 363-369 (2002). [PMID: 11751812]
  2. Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P., Messner, P.
    Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
    J. Biol. Chem. 276 : 20935-20944 (2001). [PMID: 11279237]
  3. Valvano, M. A., Messner, P., Kosma, P.
    Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
    Microbiology 148 : 1979-1989 (2002). [PMID: 12101286]
  4. Kim, M. S., Shin, D. H.
    A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 : 1110-1112 (2009). [PMID: 19923728]
  5. Taylor, P. L., Blakely, K. M., de Leon, G. P., Walker, J. R., McArthur, F., Evdokimova, E., Zhang, K., Valvano, M. A., Wright, G. D., Junop, M. S.
    Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
    J. Biol. Chem. 283 : 2835-2845 (2008). [PMID: 18056714]

[EC created 2010]