EC - Prolycopene isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
prolycopene isomerase
Other names:
carotene cis-trans isomerase
ZEBRA2 (gene name)
carotene isomerase
carotenoid isomerase
Systematic name:
7,9,7',9'-tetra-cis-lycopene cis-trans-isomerase




Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yu, Q., Ghisla, S., Hirschberg, J., Mann, V., Beyer, P.
    Plant carotene cis-trans isomerase CRTISO: a new member of the FADred-dependent flavoproteins catalyzing non-redox reactions.
    J. Biol. Chem. 286: 8666-8676 (2011). [PMID: 21209101]
  2. Li, Q., Farre, G., Naqvi, S., Breitenbach, J., Sanahuja, G., Bai, C., Sandmann, G., Capell, T., Christou, P., Zhu, C.
    Cloning and functional characterization of the maize carotenoid isomerase and ζ-carotene hydroxylase genes and their regulation during endosperm maturation.
    Transgenic Res. 19: 1053-1068 (2010). [PMID: 20221689]
  3. Isaacson, T., Ronen, G., Zamir, D., Hirschberg, J.
    Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants.
    Plant Cell 14: 333-342 (2002). [PMID: 11884678]
  4. Chai, C., Fang, J., Liu, Y., Tong, H., Gong, Y., Wang, Y., Liu, M., Wang, Y., Qian, Q., Cheng, Z., Chu, C.
    ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice.
    Plant Mol. Biol. 75: 211-221 (2011). [PMID: 21161331]

[EC created 2011]