EC - L-ribulose-5-phosphate 4-epimerase

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IntEnz Enzyme Nomenclature


Accepted name:
L-ribulose-5-phosphate 4-epimerase
Other names:
phosphoribulose isomerase
ribulose phosphate 4-epimerase
L-ribulose-phosphate 4-epimerase
L-ribulose 5-phosphate 4-epimerase
Systematic name:
L-ribulose-5-phosphate 4-epimerase




Requires a divalent cation for activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008742
CAS Registry Number: 9024-19-5
UniProtKB/Swiss-Prot: (42) [show] [UniProt]


  1. Burma, D.P. and Horecker, B.L.
    Pentose formation by Lactobacillus plantarum. IV. L-Ribulose-5-phosphate 4-epimerase.
    J. Biol. Chem. 231: 1053-1064 (1958). [PMID: 13539036]
  2. Deupree, J.D. and Wood, W.A.
    L-Ribulose 5-phosphate 4-epimerase of Aerobacter aerogenes. Evidence for nicotinamide adenine dinucleotide-independent 4-epimerization by the crystalline enzyme.
    J. Biol. Chem. 245: 3988-3995 (1970). [PMID: 4395381]
  3. Lee, N., Patrick, J.W. and Masson, M.
    Crystalline L-ribulose 5-phosphate 4-epimerase from Escherichia coli.
    J. Biol. Chem. 243: 4700-4705 (1968). [PMID: 4879898]
  4. Wolin, M.J., Simpson, F.J. and Wood, W.A.
    Degradation of L-arabinose by Aerobacter aerogenes. III. Identification and properties of L-ribulose-5-phosphate 4-epimerase.
    J. Biol. Chem. 232: 559-575 (1958). [PMID: 13549442]
  5. Andersson, A., Schneider, G. and Lindqvist, Y.
    Purification and preliminary X-ray crystallographic studies of recombinant L-ribulose-5-phosphate 4-epimerase from Escherichia coli.
    Protein Sci. 4: 1648-1650 (1995). [PMID: 8520491]
  6. Lee, L.V., Poyner, R.R., Vu, M.V. and Cleland, W.W.
    Role of metal ions in the reaction catalyzed by L-ribulose-5-phosphate 4-epimerase.
    Biochemistry 39: 4821-4830 (2000). [PMID: 10769139]
  7. Samuel, J., Luo, Y., Morgan, P.M., Strynadka, N.C.J. and Tanner, M.E.
    Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase.
    Biochemistry 40: 14772-14780 (2001). [PMID: 11732896]

[EC created 1965, modified 2005]