EC 5.1.3.36 - Heparosan-glucuronate 5-epimerase

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IntEnz Enzyme Nomenclature
EC 5.1.3.36

Names

Accepted name:
heparosan-glucuronate 5-epimerase
Other name:
HG-5epi
Systematic name:
[heparosan]-D-glucuronate 5-epimerase

Reaction

Comments:

The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Mochizuki, H., Yamagishi, K., Suzuki, K., Kim, Y. S., Kimata, K.
    Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme.
    Glycobiology 25 : 735-744 (2015). [PMID: 25677302]

[EC 5.1.3.36 created 2015]