EC 5 - Isomerases
EC 5.1 - Racemases and epimerases
EC 5.1.3 - Acting on carbohydrates and derivatives
EC 5.1.3.3 - Aldose 1-epimerase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 5.1.3.3
Names
Accepted name:
aldose 1-epimerase
Other
names:
aldose mutarotase
mutarotase
mutarotase
Systematic name:
aldose 1-epimerase
Reaction
- alpha-D-glucose = beta-D-glucose
Comments:
Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting β-D-galactose into α-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6].
Links to other databases
Protein domains and families:
PROSITE:PDOC00471
Gene Ontology:
GO:0004034
CAS Registry Number:
9031-76-9
References
-
Mutarotase from Penicillium notatum. I. Purification, assay, and general properties of the enzyme.J. Biol. Chem. 235 : 1219-1224 (1960). [PMID: 13799037]
-
Mutarotase from Penicillium notatum. II. The mechanism of the mutarotation reaction.J. Biol. Chem. 235 : 1225-1233 (1960). [PMID: 13799038]
-
Biological catalysis of mutarotation of glucose.Biochem. J. 50 : 341-348 (1952). [PMID: 14915955]
-
A rotographic study of mutarotase.Biochem. J. 57 : 50-55 (1954). [PMID: 13159947]
-
Galactose mutarotase: purification, characterization, and investigations of two important histidine residues.Biochemistry 37 : 14989-14997 (1998). [PMID: 9778377]
-
Molecular structure of human galactose mutarotase.J. Biol. Chem. 279 : 23431-23437 (2004). [PMID: 15026423]
-
The catalytic mechanism of galactose mutarotase.Protein Sci. 12 : 1051-1059 (2003). [PMID: 12717027]
[EC 5.1.3.3 created 1961]