EC 5.1.3.27 - DTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase

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IntEnz Enzyme Nomenclature
EC 5.1.3.27

Names

Accepted name:
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
Other names:
gerF (gene name)
dTDP-deoxyglucose 3-epimerase
dTDP-4-keto-6-deoxy-D-glucose 3-epimerase
dTDP-4-keto-6-deoxyglucose 3-epimerase
tylJ (gene name)
chmJ (gene name)
mydH (gene name)
Systematic name:
dTDP-4-dehydro-6-deoxy-α-D-glucose 3-epimerase

Reaction

Comments:

The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-α-D-allose, which is converted to mycinose after attachment og the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Sohng, J. K., Kim, H. J., Nam, D. H., Lim, D. O., Han, J. M., Lee, H. J., Yoo, J. C.
    Cloning, expression, and biological function of a dTDP-deoxyglucose epimerase (gerF) gene from Streptomyces sp. GERI-155.
    Biotechnol. Lett. 26: 185-191 (2004). [PMID: 15049360]
  2. Thuy, T. T., Liou, K., Oh, T. J., Kim, D. H., Nam, D. H., Yoo, J. C., Sohng, J. K.
    Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
    Glycobiology 17: 119-126 (2007). [PMID: 17053005]
  3. Kubiak, R. L., Phillips, R. K., Zmudka, M. W., Ahn, M. R., Maka, E. M., Pyeatt, G. L., Roggensack, S. J., Holden, H. M.
    Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
    Biochemistry 51: 9375-9383 (2012). [PMID: 23116432]

[EC 5.1.3.27 created 2013]