EC - N-acetylneuraminate epimerase

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IntEnz Enzyme Nomenclature


Accepted name:
N-acetylneuraminate epimerase
Other names:
sialic acid mutarotase
α-N-acetylneuraminic acid epimerase
sialic acid epimerase
Systematic name:
N-acetyl-α-neuraminate 2-epimerase



Sialoglycoconjugates present in vertebrates are linked exclusively by α-linkages and are released in α form during degradation. This enzyme accelerates maturotation to the β form (which also occurs as a slow spontaneous reaction), which is necessary for further metabolism by the bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (41) [show] [UniProt]


  1. Severi, E., Müller, A., Potts, J. R., Leech, A., Williamson, D., Wilson, K. S., Thomas, G. H.
    Sialic acid mutarotation is catalyzed by the Escherichia coli β-propeller protein YjhT.
    J. Biol. Chem. 283: 4841-4849 (2008). [PMID: 18063573]

[EC created 2011]