EC 18.104.22.168 - UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase
IntEnz Enzyme Nomenclature
2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerase
24764 [IUBMB]UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronateUDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronateName origin: UniProt - CHECKED (C)Formula: C19H25N4O18P2
Charge: -3ChEBI compound status: CHECKED (C)=
This enzyme participates in the biosynthetic pathway for UDP-α-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens . The enzyme is highly specific as UDP-α-D-GlcNAc, UDP-α-D-GlcNAcA (UDP-2-acetamido-2-deoxy-α-D-glucuronic acid) and UDP-α-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucose) cannot act as substrates .
Links to other databases
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens.Biochem. J. 405: 123-130 (2007). [PMID: 17346239]
Erratum report. Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens.Biochem. J. 405: 625 (2007).
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.Acta Crystallogr. D Biol. Crystallogr. 57: 1310-1312 (2001). [PMID: 11526328]
[EC 22.214.171.124 created 2007]