EC - Cellobiose epimerase

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IntEnz Enzyme Nomenclature


Accepted name:
cellobiose epimerase
Systematic name:
cellobiose 2-epimerase



The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of β-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047736
CAS Registry Number: 37318-37-9


  1. Tyler, T.R. and Leatherwood, J.M.
    Epimerization of disaccharides by enzyme preparations from Ruminococcus albus.
    Arch. Biochem. Biophys. 119: 363-367 (1967). [PMID: 6069974]
  2. Ito, S., Taguchi, H., Hamada, S., Kawauchi, S., Ito, H., Senoura, T., Watanabe, J., Nishimukai, M., Ito, S., Matsui, H.
    Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme.
    Appl. Microbiol. Biotechnol. 79: 433-441 (2008). [PMID: 18392616]
  3. Fujiwara, T., Saburi, W., Inoue, S., Mori, H., Matsui, H., Tanaka, I., Yao, M.
    Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar.
    FEBS Lett. 587: 840-846 (2013). [PMID: 23462136]

[EC created 1972]