EC 18.104.22.168 - Lactate racemase
IntEnz Enzyme Nomenclature
lactic acid racemase
larA (gene name)
The enzyme has been characterized from the bacterium Lactobacillus plantarum and appears to be restricted to lactic acid bacteria. It contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex.
Links to other databases
Studies on the cyclophorase system. XVII. The occurrence and properties of an α-hydroxy acid racemase.Arch. Biochem. 30: 77-89 (1951). [PMID: 14800428]
Racemase I cell-free racemase.Enzymologia 15: 259-266 (1953).
Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.J. Bacteriol. 187: 6750-6761 (2005). [PMID: 16166538]
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.Nat Commun 5: 3615 (2014). [PMID: 24710389]
METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.Science 349: 66-69 (2015). [PMID: 26138974]
From NAD+ to Nickel Pincer Complex: A Significant Cofactor Evolution Presented by Lactate Racemase.Chemistry 23: 7545-7557 (2017). [PMID: 28374531]
[EC 22.214.171.124 created 1961]