EC 5.1.1.19 - O-ureido-serine racemase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 5.1.1.19

Names

Accepted name:
O-ureido-serine racemase
Other name:
dcsC (gene name)
Systematic name:
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase

Reaction

Comments:

The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y., Sugiyama, M.
    Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
    Antimicrob. Agents Chemother. 54 : 1132-1139 (2010). [PMID: 20086163]
  2. Dietrich, D., van Belkum, M. J., Vederas, J. C.
    Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine.
    Org. Biomol. Chem. 10 : 2248-2254 (2012). [PMID: 22307920]

[EC 5.1.1.19 created 2013]