EC - Protoporphyrin ferrochelatase

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IntEnz Enzyme Nomenclature


Accepted name:
protoporphyrin ferrochelatase
Other names:
ferro-protoporphyrin chelatase
heme synthase [ambiguous]
heme synthetase [ambiguous]
iron chelatase [ambiguous]
protoheme ferro-lyase
ferrochelatase [ambiguous]
Systematic name:
protoheme ferro-lyase (protoporphyrin-forming)



The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria. The reaction is catalysed only in the reverse direction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00462
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004325
CAS Registry Number: 9012-93-5
UniProtKB/Swiss-Prot: (346) [show] [UniProt]


  1. Bloomer, J.R., Hill, H.D., Morton, K.O., Anderson-Burnham, L.A. and Straka, J.G.
    The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase.
    J.Biol. Chem. 262 : 667-671 (1987). [PMID: 3805002]
  2. Porra, R.J. and Jones, O.T.G.
    Studies on ferrochelatase. 2. An investigation of the role of ferrochelatase in the biosynthesis of various haem prosthetic groups.
    Biochem. J. 87 : 181-185 (1963). [PMID: 13972328]
  3. Porra, R.J. and Jones, O.T.G.
    Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract.
    Biochem. J. 87 : 186-192 (1963). [PMID: 13972329]

[EC created 1965, modified 2016]