EC - Guanylate cyclase

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IntEnz Enzyme Nomenclature


Accepted name:
guanylate cyclase
Other names:
guanyl cyclase
guanylyl cyclase
GTP diphosphate-lyase (cyclizing)
Systematic name:
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)



Also acts on ITP and dGTP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00425
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004383
CAS Registry Number: 9054-75-5
UniProtKB/Swiss-Prot: (111) [show] [UniProt]


  1. Garbers, D.L., Suddath, J.L. and Hardman, J.G.
    Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity.
    Biochim. Biophys. Acta 377 : 174-185 (1975). [PMID: 235291]
  2. Hardman, J.G. and Sutherland, E.W.
    Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine triphosphate.
    J. Biol. Chem. 244 : 6363-6370 (1969). [PMID: 4982201]

[EC created 1972]