EC 4.6.1.2 - Guanylate cyclase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.6.1.2
Names
Accepted name:
guanylate cyclase
Other
names:
guanyl cyclase
guanylyl cyclase
GTP diphosphate-lyase (cyclizing)
guanylyl cyclase
GTP diphosphate-lyase (cyclizing)
Systematic name:
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Reaction
-
13665 [IUBMB]GTPName origin: UniProt - CHECKED (C)Formula: C10H12N5O14P3
Charge: -4ChEBI compound status: CHECKED (C)=3',5'-cyclic GMPName origin: UniProt - CHECKED (C)Formula: C10H11N5O7P
Charge: -1ChEBI compound status: CHECKED (C)
Comments:
Also acts on ITP and dGTP.
Links to other databases
Protein domains and families:
PROSITE:PDOC00425
Gene Ontology:
GO:0004383
CAS Registry Number:
9054-75-5
References
-
Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity.Biochim. Biophys. Acta 377 : 174-185 (1975). [PMID: 235291]
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Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine triphosphate.J. Biol. Chem. 244 : 6363-6370 (1969). [PMID: 4982201]
[EC 4.6.1.2 created 1972]