EC 4.6.1.13 - Phosphatidylinositol diacylglycerol-lyase

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IntEnz Enzyme Nomenclature
EC 4.6.1.13

Names

Accepted name:
phosphatidylinositol diacylglycerol-lyase
Other names:
1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)
1-phosphatidylinositol phosphodiesterase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
Systematic name:
1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)

Reaction

Comments:

This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004436
CAS Registry Number: 37288-19-0
UniProtKB/Swiss-Prot:

References

  1. Allan, D. and Michell, R.H.
    Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0.
    Biochem. J. 142: 591-597 (1974). [PMID: 4377210]
  2. Friedel, R.O., Brown, J.D. and Durell, J.
    Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain.
    Biochim. Biophys. Acta 144: 684-686 (1967). [PMID: 4294905]
  3. Irvine, R.F.
    The enzymology of stimulated inositol lipid turnover.
    Cell Calcium 3: 295-309 (1982). [PMID: 6297738]
  4. Michell, R.H. and Allan, D.
    Inositol cyclic phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus).
    FEBS Lett. 53: 302-304 (1975). [PMID: 236918]
  5. Low, M.G. and Finean, J.B.
    Release of alkaline phosphatase fom membranes by a bacterial phosphatidylinositol phospholipase C.
    Biochem J. 167: 281-284 (1977). [PMID: 588258]
  6. Henner, D.J., Yang, M., Chen, E., Helmikss, R. and Low, M.G.
    Sequence of the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C.
    Nucleic Acids Res. 16: 10383 (1988). [PMID: 3194218]

[EC 4.6.1.13 created 1972 as EC 3.1.4.10, modified 1976, transferred 2002 to EC 4.6.1.13]