EC 4.6.1.1 - Adenylate cyclase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.6.1.1
Names
Accepted name:
adenylate cyclase
Other
names:
3',5'-cyclic AMP synthetase
adenyl cyclase
adenylylcyclase
ATP pyrophosphate-lyase
adenylyl cyclase
ATP diphosphate-lyase (cyclizing)
adenyl cyclase
adenylylcyclase
ATP pyrophosphate-lyase
adenylyl cyclase
ATP diphosphate-lyase (cyclizing)
Systematic name:
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Reaction
-
15389 [IUBMB]ATPName origin: UniProt - CHECKED (C)Formula: C10H12N5O13P3
Charge: -4ChEBI compound status: CHECKED (C)=+3',5'-cyclic AMPName origin: UniProt - CHECKED (C)Formula: C10H11N5O6P
Charge: -1ChEBI compound status: CHECKED (C)
Comments:
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+-arginine ADP-ribosyltransferase .
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00425
,
PROSITE:PDOC00837
Gene Ontology:
GO:0004016
CAS Registry Number:
9012-42-4
References
-
Adenyl cyclase of Brevibacterium liquefaciens.Biochim. Biophys Acta 149: 1-11 (1967). [PMID: 4295782]
[EC 4.6.1.1 created 1972]