EC 184.108.40.206 - Isoprene-epoxide—glutathione S-transferase
IntEnz Enzyme Nomenclature
- 2-(glutathione-S-yl)-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation. The enzyme can catalyse the glutathione-dependent ring opening of various epoxides, but the highest activity is with (3R)-3,4-epoxy-3-methylbut-1-ene, which is derived from isoprene by EC 220.127.116.11, alkene monooxygenase.
Links to other databases
A glutathione S-transferase with activity towards cis-1, 2-dichloroepoxyethane is involved in isoprene utilization by Rhodococcus sp. strain AD45.Appl. Environ. Microbiol. 64 : 2800-2805 (1998). [PMID: 9687433]
Purification of a glutathione S-transferase and a glutathione conjugate-specific dehydrogenase involved in isoprene metabolism in Rhodococcus sp. strain AD45.J. Bacteriol. 181 : 2094-2101 (1999). [PMID: 10094686]
[EC 18.104.22.168 created 2016]