EC 4.4.1.22 - S-(hydroxymethyl)glutathione synthase

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IntEnz Enzyme Nomenclature
EC 4.4.1.22

Names

Accepted name:
S-(hydroxymethyl)glutathione synthase
Other names:
glutathione-dependent formaldehyde-activating enzyme
Gfa
S-(hydroxymethyl)glutathione formaldehyde-lyase
Systematic name:
S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)

Reaction

Comments:

The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051907
UniProtKB/Swiss-Prot: (30) [show] [UniProt]

References

  1. Goenrich, M., Bartoschek, S., Hagemeier, C.H., Griesinger, C., Vorholt, J.A.
    A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy.
    J. Biol. Chem. 277 : 3069-3072 (2002). [PMID: 11741920]

[EC 4.4.1.22 created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 4.4.1.22)]