EC - Holocytochrome-c synthase

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IntEnz Enzyme Nomenclature


Accepted name:
holocytochrome-c synthase
Other names:
cytochrome c heme-lyase
holocytochrome c synthetase
cytochrome c synthase
holocytochrome-c apocytochrome-c-lyase
Systematic name:
holocytochrome-c apocytochrome-c-lyase (heme-forming)



In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00647
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004408
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Dumont, M.E., Ernst, J.F., Hampsey, D.M. and Sherman, F.
    Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae.
    EMBO J. 6: 235-241 (1987). [PMID: 3034577]

[EC created 1990]