EC 4.3.99.4 - Choline trimethylamine-lyase

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IntEnz Enzyme Nomenclature
EC 4.3.99.4

Names

Accepted name:
choline trimethylamine-lyase
Other name:
cutC (gene name)
Systematic name:
choline trimethylamine-lyase (acetaldehyde-forming)

Reaction

Comments:

The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Craciun, S., Balskus, E. P.
    Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.
    Proc. Natl. Acad. Sci. U.S.A. 109 : 21307-21312 (2012). [PMID: 23151509]

[EC 4.3.99.4 created 2013]