EC - 7-carboxy-7-deazaguanine synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
7-carboxy-7-deazaguanine synthase
Other names:
7-carboxy-7-carbaguanine synthase
queE (gene name)
Systematic name:
6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase




Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (40) [show] [UniProt]


  1. McCarty, R. M., Somogyi, A., Lin, G., Jacobsen, N. E., Bandarian, V.
    The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.
    Biochemistry 48 : 3847-3852 (2009). [PMID: 19354300]

[EC created 2012]