EC 4.3.99.3 - 7-carboxy-7-deazaguanine synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.3.99.3
Names
Accepted name:
7-carboxy-7-deazaguanine synthase
Other
names:
7-carboxy-7-carbaguanine synthase
queE (gene name)
queE (gene name)
Systematic name:
6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
Reaction
- 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
Cofactors
Comments:
Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
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DIAGRAM
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ExplorEnz
,
ENZYME@ExPASy
,
KEGG
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MetaCyc
,
UniPathway
References
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The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.Biochemistry 48 : 3847-3852 (2009). [PMID: 19354300]
[EC 4.3.99.3 created 2012]