EC 4.3.3.5 - 4'-demethylrebeccamycin synthase

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IntEnz Enzyme Nomenclature
EC 4.3.3.5

Names

Accepted name:
4'-demethylrebeccamycin synthase
Other names:
arcyriaflavin A N-glycosyltransferase
RebG
Systematic name:
4'-demethylrebeccamycin D-glucose-lyase

Reaction

Comments:

This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Ohuchi, T., Ikeda-Araki, A., Watanabe-Sakamoto, A., Kojiri, K., Nagashima, M., Okanishi, M., Suda, H.
    Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccarothrix aerocolonigenes ATCC39243.
    J. Antibiot. 53 : 393-403 (2000). [PMID: 10866221]
  2. Zhang, C., Albermann, C., Fu, X., Peters, N. R., Chisholm, J. D., Zhang, G., Gilbert, E. J., Wang, P. G., Van Vranken, D. L., Thorson, J. S.
    RebG- and RebM-catalyzed indolocarbazole diversification.
    Chembiochem 7 : 795-804 (2006). [PMID: 16575939]

[EC 4.3.3.5 created 2010]