EC - Strictosidine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
strictosidine synthase
Other names:
strictosidine synthetase
3-α(S)-strictosidine tryptamine-lyase
Systematic name:
3-α(S)-strictosidine tryptamine-lyase (secologanin-forming)



Catalyses a a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016844


  1. Treimer, J.K. and Zenk, M.H.
    Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation.
    Eur. J. Biochem. 101 : 225-233 (1979). [PMID: 510306]
  2. Kutchan, T.M.
    Strictosidine: from alkaloid to enzyme to gene.
    Phytochemistry 32 : 493-506 (1993). [PMID: 7763429]
  3. de Waal, A., Meijer, A.H. and Verpoorte, R.
    Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms.
    Biochem. J. 306 ( : 571-580 (1995). [PMID: 7887913]
  4. Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. and Stöckigt, J.
    Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system.
    Planta 222 : 888-898 (2005). [PMID: 16133216]
  5. McCoy, E., Galan, M.C. and O'Connor, S.E.
    Substrate specificity of strictosidine synthase.
    Bioorg. Med. Chem. Lett. 16 : 2475-2478 (2006). [PMID: 16481164]
  6. Ma, X., Panjikar, S., Koepke, J., Loris, E., Stöckigt, J.
    The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins.
    Plant Cell 18 : 907-920 (2006). [PMID: 16531499]

[EC created 1990]