EC 4.3.2.8 - γ-glutamylamine cyclotransferase

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IntEnz Enzyme Nomenclature
EC 4.3.2.8

Names

Accepted name:
γ-glutamylamine cyclotransferase
Other name:
GGACT
Systematic name:
ε-(γ-L-glutamyl)-L-lysine γ-glutamyl cyclotransferase (5-oxo-L-proline producing)

Reaction

Comments:

The enzyme, found in vertebrates, has no activity toward α-(γ-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, γ-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the γ-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0061929
UniProtKB/Swiss-Prot:

References

  1. Fink, M. L., Chung, S. I., Folk, J. E.
    gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
    Proc. Natl. Acad. Sci. U.S.A. 77: 4564-4568 (1980). [PMID: 6107907]
  2. Oakley, A. J., Coggan, M., Board, P. G.
    Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.
    J. Biol. Chem. 285: 9642-9648 (2010). [PMID: 20110353]

[EC 4.3.2.8 created 2017]