EC 4.2.99.24 - Thebaine synthase

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IntEnz Enzyme Nomenclature
EC 4.2.99.24

Names

Accepted name:
thebaine synthase
Other name:
THS
Systematic name:
(7S)-salutaridinol 7-O-acetate acetate-lyase (thebaine forming)

Reaction

Comments:

Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Chen, X., Hagel, J. M., Chang, L., Tucker, J. E., Shiigi, S. A., Yelpaala, Y., Chen, H. Y., Estrada, R., Colbeck, J., Enquist-Newman, M., Ibanez, A. B., Cottarel, G., Vidanes, G. M., Facchini, P. J.
    A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis.
    Nat. Chem. Biol. 14: 738-743 (2018). [PMID: 29807982]

[EC 4.2.99.24 created 2019]