EC 4.2.3.97 - (-)-δ-cadinene synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.97

Names

Accepted name:
(-)-δ-cadinene synthase
Systematic name:
(2E,6E)-farnesyl diphosphate diphosphate-lyase (cyclizing, (-)-δ-cadinene-forming)

Reaction

Comments:

The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-δ-cadinene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hu, Y., Chou, W. K., Hopson, R., Cane, D. E.
    Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.
    Chem. Biol. 18: 32-37 (2011). [PMID: 21276937]

[EC 4.2.3.97 created 2012]