EC 4.2.3.96 - Avermitilol synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.96

Names

Accepted name:
avermitilol synthase
Systematic name:
avermitilol hydrolase (cyclizing, avermitilol-forming)

Reaction

Cofactor

Comments:

Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Chou, W. K., Fanizza, I., Uchiyama, T., Komatsu, M., Ikeda, H., Cane, D. E.
    Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
    J. Am. Chem. Soc. 132 : 8850-8851 (2010). [PMID: 20536237]

[EC 4.2.3.96 created 2012]