EC 4.2.3.86 - 7-epi-α-selinene synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.86

Names

Accepted name:
7-epi-α-selinene synthase
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-α-selinene-forming)

Reaction

Comments:

The recombinant enzyme from Vitis vinifera forms 49.5% (+)-valencene (cf. EC 4.2.3.73, valencene synthase) and 35.5% (-)-7-epi-α-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102906
UniProtKB/Swiss-Prot:

References

  1. Lucker, J., Bowen, P., Bohlmann, J.
    Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries.
    Phytochemistry 65: 2649-2659 (2004). [PMID: 15464152]
  2. Martin, D. M., Toub, O., Chiang, A., Lo, B. C., Ohse, S., Lund, S. T., Bohlmann, J.
    The bouquet of grapevine (Vitis vinifera L. cv. Cabernet Sauvignon) flowers arises from the biosynthesis of sesquiterpene volatiles in pollen grains.
    Proc. Natl. Acad. Sci. U.S.A. 106: 7245-7250 (2009). [PMID: 19359488]

[EC 4.2.3.86 created 2011]