EC 4.2.3.74 - Presilphiperfolanol synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.74

Names

Accepted name:
presilphiperfolanol synthase
Other names:
BcBOT2
CND15
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8β-ol-forming)

Reaction

Cofactor

Comments:

Requires Mg2+. Presilphiperfolan-8β-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Pinedo, C., Wang, C. M., Pradier, J. M., Dalmais, B., Choquer, M., Le Pecheur, P., Morgant, G., Collado, I. G., Cane, D. E., Viaud, M.
    Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea.
    ACS Chem. Biol. 3 : 791-801 (2008). [PMID: 19035644]
  2. Wang, C. M., Hopson, R., Lin, X., Cane, D. E.
    Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8β-ol.
    J. Am. Chem. Soc. 131 : 8360-8361 (2009). [PMID: 19476353]

[EC 4.2.3.74 created 2011]