EC - (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)

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IntEnz Enzyme Nomenclature


Accepted name:
(4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)
Other names:
phellandrene synthase
(−)-β-phellandrene synthase
(−)-(4S)-β-phellandrene synthase
Systematic name:
geranyl-diphosphate diphosphate-lyase [cyclizing; (4S)-β-phellandrene-forming]




Requires Mn2+. Mg2+ is not effective [1]. Some (−)-α-phellandrene is also formed [3]. The reaction involves a 1,3-hydride shift [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Savage, T. J., Hatch, M. W., Croteau, R.
    Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase.
    J. Biol. Chem. 269: 4012-4020 (1994). [PMID: 8307957]
  2. Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S., Croteau, R.
    cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
    Arch. Biochem. Biophys. 368: 232-243 (1999). [PMID: 10441373]
  3. Wagschal, K., Savage, T.J. and Croteau, R.
    Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases.
    Tetrahedron 31: 5933-5944 (1991).
  4. LaFever, R. E., Croteau, R.
    Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene.
    Arch. Biochem. Biophys. 301: 361-366 (1993). [PMID: 8460944]

[EC created 2010]