EC 4.2.3.39 - epi-cedrol synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.39

Names

Accepted name:
epi-cedrol synthase
Other names:
8-epicedrol synthase
epicedrol synthase
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)

Reaction

Cofactor

Comments:

The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins α-cedrene, β-cedrene, (E)-β-farnesene and (E)-α-bisabolene [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052682
UniProtKB/Swiss-Prot:

References

  1. Mercke, P., Crock, J., Croteau, R. and Brodelius, P.E.
    Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.
    Arch. Biochem. Biophys. 369 : 213-222 (1999). [PMID: 10486140]
  2. Hua, L. and Matsuda, S.P.T.
    The molecular cloning of 8-epicedrol synthase from Artemisia annua.
    Arch. Biochem. Biophys. 369 : 208-212 (1999). [PMID: 10486139]

[EC 4.2.3.39 created 2009]