EC - Stemar-13-ene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
stemar-13-ene synthase
Other names:
stemarene synthase
syn-stemar-13-ene synthase
Systematic name:
9α-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming)



This diterpene cyclase produces stemar-13-ene, a putative precursor of the rice phytoalexin oryzalexin S. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034278


  1. Mohan, R.S., Yee, N.K.N., Coates, R.M., Ren, Y.-Y., Stamenkovic, P., Mendez, I. and West, C.A.
    Biosynthesis of cyclic diterpene hydrocarbons in rice cell suspensions: conversion of 9,10-syn-labda-8(17),13-dienyl diphosphate to 9β-pimara-7,15-diene and stemar-13-ene.
    Arch. Biochem. Biophys. 330: 33-47 (1996). [PMID: 8651702]
  2. Nemoto, T., Cho, E.-M., Okada, A., Okada, K., Otomo, K., Kanno, Y., Toyomasu, T., Mitsuhashi, W., Sassa, T., Minami, E., Shibuya, N., Nishiyama, M., Nojiri, H. and Yamane, H.
    Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice.
    FEBS Lett. 571: 182-186 (2004). [PMID: 15280039]

[EC created 2008]