EC - Methylglyoxal synthase

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IntEnz Enzyme Nomenclature


Accepted name:
methylglyoxal synthase
Other names:
methylglyoxal synthetase
glycerone-phosphate phospho-lyase
Systematic name:
glycerone-phosphate phosphate-lyase (methylglyoxal-forming)



Does not act on D-glyceraldehyde 3-phosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC01037
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008929
CAS Registry Number: 37279-01-9
UniProtKB/Swiss-Prot: (230) [show] [UniProt]


  1. Cooper, R.A. and Anderson, A.
    The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli.
    FEBS Lett. 11 : 273-276 (1970). [PMID: 11945504]
  2. Hopper, D.J. and Cooper, R.A.
    The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis?
    FEBS Lett. 13 : 213-216 (1971). [PMID: 11945670]
  3. Ray, S. and Ray, M.
    Isolation of methylglyoxal synthase from goat liver.
    J. Biol. Chem. 256 : 6230-6233 (1981). [PMID: 7240200]

[EC created 1972 as EC, transferred 2000 to EC]