EC - (2S,3R,6S,9S)-(−)-protoillud-7-ene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
(2S,3R,6S,9S)-(−)-protoillud-7-ene synthase
Other name:
TPS6 (gene name)
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2S,3R,6S,9S)-(−)-protoillud-7-ene-forming]



The enzyme has been described from the slime-mould Dictyostelium discoideum. It is specific for (2E,6E)-farnesyl diphosphate. While the major product is the sequiterpene (2S,3R,6S,9S)-(−)-protoillud-7-ene, traces of pentalenene are also formed.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Chen, X., Kollner, T. G., Jia, Q., Norris, A., Santhanam, B., Rabe, P., Dickschat, J. S., Shaulsky, G., Gershenzon, J., Chen, F.
    Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae.
    Proc. Natl. Acad. Sci. U.S.A. 113 : 12132-12137 (2016). [PMID: 27790999]
  2. Rabe, P., Rinkel, J., Nubbemeyer, B., Kollner, T. G., Chen, F., Dickschat, J. S.
    Terpene Cyclases from Social Amoebae.
    Angew. Chem. Int. Ed. Engl. 55 : 15420-15423 (2016). [PMID: 27862766]

[EC created 2017]