EC 4.2.3.150 - Cembrene A synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.150

Names

Accepted name:
cembrene A synthase
Other name:
DtcycB (gene name)
Systematic name:
geranylgeranyl-diphosphate diphosphate-lyase [(R)-cembrene-A-forming]

Reaction

Cofactors

Comments:

Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC 4.2.3.149, nephthenol synthase and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Meguro, A., Tomita, T., Nishiyama, M., Kuzuyama, T.
    Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.
    Chembiochem 14: 316-321 (2013). [PMID: 23386483]

[EC 4.2.3.150 created 2014]